Bioengineers Testing The Smart Insulin Patch, A Team Of Bioengineers Has Developed A Glucose Responsive Insulin Patch Of U.S. A team of American bioengineers has developed a glucose-sensitive insulin patch that can one day control and control glucose levels in people with diabetes.
Researchers have successfully tested patches in diabetic mice and insulin-deficient minipigs, and are now seeking FDA approval of clinical trials in humans. Smart insulin patch Image by Jane Gu Lab, University of California, Los Angeles.
“This smart patch eliminates the need to continually monitor the blood sugar level and then inject insulin when necessary. It mimics the regulatory function of the pancreas but in an easy to use way. “
The team’s adhesive patch controls blood sugar or glucose. Your insulin dose is filled in a very low micrononal, less than a millimeter in length that quickly administers the medication when blood sugar levels reach a certain threshold.
When blood sugar returns to normal, the administration of insulin from the patch also slows down. “The advantage is that it can help prevent an insulin overdose, causing hypoglycemia, seizures, coma or even death,” the scientists said.
The micrononal used in patches are made with a glucose sensor polymer encapsulated with insulin. Once applied to the skin, the microneedles penetrate under the skin and can feel blood sugar levels. If glucose levels increase, the polymer is fired to release insulin.
Each microneedle is smaller than a common needle that is used to draw blood and does not reach depth, so the patch is less painful than a puncture. Each microneedle penetrates approximately half a millimeter under the skin, which is enough to administer insulin to the body.
In new experiments, the smart patch successfully monitored glucose levels in minipugs with type I diabetes for approximately 20 hours. MIT Professor Robert Langer, co-author of the study, said: “I am delighted that the team can take this smart insulin patch one step closer to reality.
UCLA researchers develop smart coin-shaped insulin patches. UCLA Bioengineers and its partners have developed a smart insulin delivery patch that can monitor and control one day in people with diabetes and provide the required insulin dose.
The adhesive patch, about the size of a quarter, is easy to manufacture and designed to run 24 hours before it needs to be replaced. A study describing research in which patches were tested in mice and pigs was published in Nature Biomedical Engineering.
“Our primary goal is to improve the health and improve the quality of life for people with diabetes,” said study leader Jen Gu, a professor of bioengineering at UCLA’s Samuli School of Engineering.
This smart patch eliminates the need to continuously monitor your blood sugar level and then inject insulin when necessary. It mimics the regulatory function of the pancreas, but is easy to use in this way. Schematic mechanism of the glucose-sensitive smart insulin patch.
The smart patch monitors blood sugar (or glucose). It contains insulin doses in very few micronodels, which are less than 1 millimeter in length, when the blood glucose levels reach a certain threshold, the drug is administered quickly.
When blood sugar returns to normal, your insulin supply also slows down. The researchers said the advantage is that it can help prevent insulin overdose, which can lead to hypoglycemia, seizures, coma, or even death.
“It has always been a dream to achieve insulin delivery in a smart and convenient way,” study co-author Dr. Said John Beauce, director of the University of North Carolina Diabetes Center at Chapel and the Institute of Translational and Clinical Sciences. Hill School of Medicine.
This smart insulin patch, if proven safe and effective in human trials, will revolutionize the diabetes patient experience. Insulin is a hormone that occurs naturally in the pancreas. It helps the body regulate glucose, which comes from eating food and provides energy to the body.
Insulin is the molecular key that helps transfer glucose from cells in the blood for energy and storage. Diabetes occurs when a person’s body does not naturally produce insulin (type 1 diabetes) or does not use efficiently produced insulin (type 2).
In any case, a regular dose of insulin is prescribed to control the disease, which affects more than 400 million people worldwide. Not much has changed in decades of treatment for the disease in most parts of the world. Diabetes patients will draw their blood using a device that measures glucose levels.
They will then self-administer a required dose of insulin. Insulin can be injected with a needle and syringe, administered by a pen-like device, or an insulin pump, which is a portable device the size of a cell phone connected to the body through a tube with a needle in the extreme.
The micrononels used in the patch are made with an insulin encapsulated glucose sensor polymer. Once applied to the skin, the microneedles penetrate under the skin and can feel the blood sugar levels. If glucose levels rise, the polymer triggers to release insulin.
The microneedle is smaller than a common needle used to draw blood, and it does not reach depth either, making it less painful than a puncture. It penetrates approximately half a millimeter under the skin, which is enough to administer insulin to the body.
In experiments, a quarter-size patch successfully controlled glucose levels in pigs with type I diabetes for approximately 20 hours. The pigs weighed on average about 55 pounds. The technology has been accepted into the Emerging Technology Program of the US Food and Drug Administration.
USA, which helps companies during the regulatory process. The researchers are requesting FDA approval for human clinical trials, which they believe could begin in a few years. The team imagined that the smart microneedle patches could be adapted with different medications to control other medical conditions.
At UCLA, Gu Jonson is also a member of the Comprehensive Cancer Center, the California Institute of Nano Systems, and the Minimally Invasive Therapy Center. The study, backed by Xenomics, a UCLA-based startup, also includes authors from North Carolina State University.
The University of North Carolina at Chapel Hill, the Institute of Technology. This coin-shaped smart insulin patch can control glucose to control diabetes.Researchers from three universities have developed a smart insulin delivery patch that has the ability to monitor and control glucose levels in people with diabetes.
The adhesive patch was developed by a team of researchers and bioengineers from UCLA, the University of North Carolina School of Medicine and the Massachusetts Institute of Technology. It is the size of a coin and can be easily manufactured for single use.
The research on the smart insulin patch was done in mice and pigs and in 2015 it was successful in mouse testing at UNC. The team is now seeking FDA approval for human clinical trials.
Our main goal is to improve the health and improve the standard of living of people with diabetes, Professor Jane Gu of Bioengineering and UCLA said in a press release. This smart patch eliminates the need to continuously monitor your blood sugar level and then inject insulin when necessary.It mimics the regulatory function of the pancreas but in a user-friendly way.
The adhesive patch monitors blood sugar and pre-filled insulin doses in small microns on the patch to deliver the medication quickly when glucose levels reach a certain level. Once glucose levels return to the normal range, insulin delivery slows down.
“It has always been a dream to administer insulin intelligently and conveniently,” said study co-author John Buse. “This smart insulin patch, if proven safe and effective in human trials, will revolutionize the patient experience in diabetes care.”
The microneedles in the patch are made of a glucose-sensing polymer that bonds with insulin. Once the patch is on the skin, the microneedles penetrate under the skin and begin to feel glucose levels.If glucose changes, the polymers in the patch release insulin through microneedles, which are less than 1mm in length. The microneedles penetrate up to half a millimeter under the skin.
When tested in pigs, the patch was able to control glucose levels in type 1 diabetes for up to 20 hours. Study co-author Robert Lander said: “I am delighted that the team can take this smart insulin patch one step closer to reality, and we hope to one day take a step forward to help people with diabetes.”
The researchers plan to expand the device’s drug delivery application outside of insulin to be tested once successfully in humans. The research was published in the journal Nature Biomedical Engineering and was supported by Xenomics, a UCLA-based startup.
Researchers are requesting FDA approval for clinical trials in humans, which they believe could begin within a few years.