Common human Coronavirus without seasonal form, study wise. According to a study by the University of Michigan School of Public Health, four types of human coronaviruses (OC43, 229E, HKU1, and NL63) are highly seasonal and are transmitted in the same population as influenza A (H3N2).
The study authors say it’s not possible to know if SARS-CoV-2, a new coronavirus that causes COVID-19 disease, will behave the same way, but their findings are expected to give scientists COVID-19. to better prepare for the weather during the epidemic.
The study was published in the Journal of Infectious Diseases. “Although the seasonal coronaviruses found in Michigan are linked to the SARS-CoV-2 virus, we have no idea if this virus will explain how these seasonal viruses will behave in the future,” said study lead author Professor Arnold Monto. .
“Only time will tell whether SARS-CoV-2 will become a continuous presence in the landscape of respiratory infection, continue with limited circulation with MERS, or, like SARS, disappear entirely from humans.”
Professor Monto and his colleagues used data from the Domestic Influenza Vaccine Evaluation (HIVE) study, a longitudinal investigation of respiratory diseases in households with children in the Ann Arbor, Michigan area.
During the past 10 years, between 890 and 1,441 individuals participated in hundreds of studied homes. The study now tracks the occurrence of SARS-CoV-2 and its possible involvement in Michigan households.
In 2010, it began tracking the appearance of four types of human coronaviruses. Professor Monto and his co-authors analyzed the frequency, seasonal and domestic transmission characteristics of 993 infections due to these coronaviruses and infections:
- (i) When year-over-year surveillance was ongoing, most coronavirus cases were detected between December and April / May and peaked in January / February; Only 2.5% of the cases occurred between June and September;
- (ii) the highest frequency of infection was in children younger than 5 years;
- (iii) of 993 infections, 260 were obtained from infected domestic contact;
- (iv) the serial interval between the index and home-acquired cases ranged from 3.2 to 3.6 days; The risk of secondary infection ranged from 7.2% to 12.6%;
- (v) Overall, 6% of adult cases and 20% of child cases were related to doctor visits; On average, 30% of influenza cases require a visit to the doctor;
- (vi) Children under the age of 5 and children over the age of 50 are more likely to be severely classified.
The common coronavirus viruses studied are increasingly seasonal in Michigan and appear based on serial endpoints and risk of secondary infection, with H3N2-like transmission capacity in the same population.
“The results do not necessarily reflect how the new SARS-CoV-2 coronavirus will behave,” the researchers said. In another ongoing study, they are using samples collected prior to the SARS-CoV-2 pandemic to observe the introduction of that virus into the community.
Preliminary results show no evidence that the new coronavirus was present in the community before March. Common coronaviruses are highly seasonal with most cases in winter. According to a new study by researchers at the University of Michigan School of Public Health, four out of seven coronaviruses known to infect people cause common respiratory infections that are rapidly seasonal and transmitted similarly to influenza.
The study authors state that it is not possible to determine whether the SARS-CoV-2 coronavirus, which causes COVID-19 disease, will behave the same way. But he hopes his findings will help researchers better prepare for the COVID-19 epidemic. Their study appears in the Journal of Infectious Diseases.
“Despite the fact that seasonal coronaviruses found in Michigan are related to SARS-CoV-2, we do not know if the virus will behave like seasonal coronaviruses,” said Collegiate Professor of Epidemiology Thomas Franco at the UM School of Public Schools , Arnold Monto – Health.
Only time will tell whether SARS-CoV-2 will become a constant presence on the stage of respiratory infection, continue with limited circulation with MERS, or, like SARS, disappear entirely from humans.”
Researchers have noted that while coronaviruses have long been recognized as human respiratory pathogens, human coronaviruses have historically been detected in mild respiratory diseases; However, when coronaviruses from animals spread to humans, they can cause serious illness.
Severe Acute Respiratory Syndrome (SARS) emerged in 2002 and Middle East Respiratory Syndrome (MERS) in 2012 when a coronovirus jumped from an animal into people. The COVID-19 epidemic is believed to have started in the same way.
Monto and colleagues used data from the Domestic Influenza Vaccine Assessment Study, a longitudinal investigation of respiratory illness in households with children in the Ann Arbor area. Over the past 10 years, 890 to 1,441 people from several hundred households participated in the study.
Ongoing studies are now tracking the occurrence of SARS-CoV-2 and its possible presence in Michigan homes. In 2010, the study began tracking the emergence of four typically mild human coronaviruses (OC43, 229E, HKU1, and NL63).
The researchers analyzed the frequency, season, and home transmission characteristics of the 993 infections that caused those coronaviruses. They found: Overall, 9% of adult cases and 20% of children were associated with doctor visits. On average, 30% of influenza cases require a visit to the doctor.
When monitored throughout the year, most coronavirus cases were detected between December and April / May and peaked in January / February. Only 2.5% of cases occurred between June and September. The highest frequency of infection was in children younger than 5 years.
Of 993 infections, 260 were obtained from infected household contact. The serial interval between the index and home-acquired cases ranged from 3.2 to 3.6 days. The risk of secondary infection ranged from 7.2% to 12.6% by type. Cases in children younger than 5 years and adults older than 50 years were more likely to be classified as severe.
Monto and colleagues claim that the coronaviruses studied are increasingly seasonal in Michigan and appear based on serial endpoints and the risk of secondary infection, leading to a transmission capacity similar to influenza A (H3N2) virus. ) in the study population Es.
They say that the results are not indicative of how SARS-CoV-2 will behave. In a separate ongoing study, researchers are using samples collected prior to the COVID-19 pandemic to detect community introduction of SARS-CoV-2.
Preliminary results show no evidence that SARS-CoV-2 existed in the community before March. The study was funded by the National Institutes of Allergy and Infectious Diseases, part of the National Institutes of Health, through grants R01 AI097150 and R56 AI097150.
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Coronavirus occurrence and transmission for 8 years in a cohort of HIV-positive households in Michigan. Journal of Infectious Diseases, published online April 10, 2020
Understanding the genome sequences helps researchers choose the correct strain of the SARS-CoV-2 virus for vaccines and clinical efforts. The first 181 published SARS-CoV-2 genomes were analyzed to understand how changes in the virus can affect its behavior and effects.
This RNA virus is expected to evolve into many different groups that share the mutation that we have confirmed and visualized, said Professor SS Vasan, leader of the CSIRO dangerous pathogens team and researcher at York University.
“At this time, we do not expect this to affect the development and evaluation of COVID-19 vaccines, therapy, and diagnosis, but it is important information to monitor as preclinical and clinical studies progress.”
To enable this, we are asking the international research community to share unidentified information about the severity of the case and the results and other relevant metadata such as comorbidity and smoking with genomic sequences of the virus.” Huh. “
This study demonstrates the importance of cross collaboration between established and emerging disciplines of bioinformatics, genomics, vaccinology, and virology. CEO of CSIRO’s Australian Center for Electronic Health Research, Dr. “This is a critically important component of CSIRO’s response after a peer-reviewed scientific process like this,” said David Henson.
The team’s article was published in a magazine called Transboundary and Emerging Diseases.