The Paper-Based Device Can Detect SARS-CoV-2

The paper-based device can detect SARS-CoV-2 coronavirus in wastewater

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The paper-based device can detect SARS-CoV-2 coronavirus in wastewater. An approach called waste-based epidemiology (WBE), which is already recognized as an effective way to detect illegal drugs and obtain information on health, diseases and pathogens, the possible spread of SARS. It can provide a quick and effective way to predict – cov -2. A new coronavirus by detecting biomarkers in faeces and urine of disease carriers entering the sewer system, causing COVID-19 disease.

A quick test kit with a paper-based device can be used to locate sources in wastewater treatment plants and determine if there are potential carriers in local areas. The paper device appears in steps to fold and filter pathogen nucleic acids from waste material samples, then a biochemical reaction with pre-loaded reagents reveals whether nucleic acid from SARS-COV-2 infection is present.

The results are visible to the naked eye: a green circle represents a positive and a blue circle represents a negative. Image from Cranefield University. The recent COVID-19 outbreak has spread rapidly around the world and cases have now been confirmed in 130 countries around the world.

Some clinical cases have found that some carriers of the virus can be asymptomatic, without fever, without more or with minor symptoms of infection. Without the ability to quickly and effectively screen these asymptomatic patients, these untreated carriers have the potential to increase the risk of disease transmission if initial effective quarantine measures are not implemented.

Therefore, the rapid and accurate detection of possible virus carriers and the diagnosis of asymptomatic patients is an important step for intervention and prevention in early stages, to detect unknown sources of SARS-CoV-2.

“In the case of asymptomatic infection in the community or when people are not sure whether they are infected or not, real-time detection of feces from the community through paper-based analytical tools can be determined by allowing whether SARS carriers -CoV-2 are in an area of detection.

And quarantine & prevention, “said lead author Dr. Xugen Yang of Cranfield University. Said a lecturer and head technology. If SARS-VOC-2DN can be monitored in a community at an early stage through the WRS.

And then effective interventions can be taken to restrict the movements of that local population as soon as possible, reducing the prevalence of pathogens Do and is in public health risk. Live SARS-CoV-2 virus can be isolated from the feces and urine of infected people, and the virus can generally survive for several days in a suitable environment after leaving the human body.

The kit’s paper device is filtered and opened to filter out pathogenic nucleic acids from the wastewater samples, then a biochemical reaction with pre-loaded reagents shows that the nucleic acid present in the SARS-CoV-2 OR transition is not

The results are visible to the naked eye: a green circle represents a positive and a blue circle represents a negative. We have already developed a paper device to test genetic material in waste matter as proof of concept, and it provides a clear ability to test infection with adaptation, Dr. Yang said.

This tool is inexpensive and will be easy for non-specialists to use after further improvements. We hope that the device can present a complete and immediate picture of the health of the population after this sensor is implemented in the near future. The team’s work was published in the journal Environmental Science and Technology.

Can the paper-based device track the wastewater-based epidemiology of COVID-19? Environment. Science. Technol, published online March 23, 2020; doi: 10.1021 / acs.est.0c01174

Wastewater testing can provide an early warning for COVID-19. Researchers at Cranfield University are working on a new test to detect SARS-CoV-2 in sewage from virus-infected communities. The wastewater-based epidemiology (WBE) approach can provide an effective and rapid way to predict the possible spread of novel coronavirus pneumonia (COVID-19) in biomarkers in faeces and urine of disease carriers entering the sewer system.

Rapid test kits using paper-based devices can be used to locate on-site sources in wastewater treatment plants and determine if there are potential COVID-19 carriers in local areas. Professor of Sensor Technology at the Cranfield Institute for Water Sciences, Dres. Zugen Yang said:

“In the case of asymptomatic infection in the community or when people are not sure whether they are infected or not, community adaptation can be detected in real time through paper analytical tools. Determine if a region has COVID-19 carriers to enable rapid detection, quarantine and prevention.

“If COVID-19 can be monitored at an early stage in a community through VMs, it can intervene as soon as possible to restrict the movements of that local population, reducing the prevalence of pathogens making and posing a threat to public health. “

Recent studies have shown that SARS-VOC-2 can be isolated from the feces and urine of infected people, and the virus can generally survive for several days in a suitable environment after leaving the human body.

The paper device is closed and developed in steps to filter pathogenic nucleic acids from waste material samples, then a biochemical reaction with pre-loaded reagents reveals whether nucleic acid from SARS-COV-2 infection is present. it is. The results are visible to the naked eye: a green circle represents a positive and a blue circle represents a negative.

Dr. “We have already developed a paper device to test genetic material in wastewater for the concept, and it provides a clear ability to detect infections,” said Yang. “This tool is cheaper (costs less than £ 1) and will be easier for non-specialists to use after further improvements.

“We hope that the device can present a complete and immediate picture of the health of the population after this sensor is implemented in the near future.” The WBE is already recognized as an effective way to detect illegal drugs and obtain information on health, diseases and pathogens.

Dr. Yang has developed a similar paper-based tool for rapid veterinary diagnosis in India and for detecting blood malaria among rural Uganda populations. Paper analytical instruments are easy to stack, store and transport because they are thin and light and can deteriorate even after use, reducing the risk of further contamination.

Approach overview: Can a paper device trace the source of COVID-19 with waste-based epidemiology? – Co-authored with the Institute of Geochemistry, the Chinese Academy of Sciences, Hua Zhang and Kang Mao of Guiyang, China, recently appeared in the journal Environmental Science and Technology.

Further development of the test is being sponsored by the Natural Environment Research Council (NERC) and the Royal Academy of Engineering.

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