The Scientists Made A Molecular Map Of The Striatum

Scientists created a molecular map of the striatum. The striatum, the inner part of the brain, is considered essential for decision making and the development of various addictions. Methods used in mouse models and to map brain cell and tissue types.

A team of researchers from the Karolinska Institute in Sweden were able to visualize the organization of various opioid islands in the striatum. Focusing on the characterization of patches and matrix compartments.

Genetic labeling of neurons that express the Mu opioid receptor reveals the identity of the neuron subtypes and also establishes spatial markers for the identification of subparts in the striatum. In the study, Drs. Constantine Melatis and his colleagues created a 3D molecular map of the nerve cells attacked by opioids and showed how they organize in the striatum.

“Our map is the basis for a new understanding of brain networks, arguably the most important for decision making,” said Dr. Meletis said. “This may contribute to a better understanding of common reward processes and the effects of various addictive substances on this network.”

To find this molecular code, the researchers used single-core RNA sequencing, a method of studying small differences in individual cells and mapping the expression of the separation gene.

The results provide the first demonstration of molecular codes that divide the striatum into three main levels of classification: a spatial organization, a patch matrix, and a specific cell-type organization.

“With this new knowledge, we can now begin to analyze the function of different types of nerve cells in different molecularly defined regions,” said Dr. Meletis said. “This is the first step to directly define the role of networks in decision making and addiction control with the help of optogenetics.”

The scientists said this new knowledge could also form the basis for the development of new therapies based on a mechanistic understanding of brain therapy. The development of the new Salem map is described in an article in Cell Reports magazine.

Scientists made a molecular map of the stratum. The striatum, the inner part of the brain, is considered central to decision making and the development of various addictions. Using methods used in mouse models and to map brain tissue and cell types.

A team of researchers from the Karolinska Institute in Sweden were able to visualize the organization of various opioid islands in the striatum. Märtin et al define the molecular identity of striatal projection neurons, focusing on the characterization of patches and matrix compartments.

Genetic labeling of neurons that express the Mu opioid receptor (Oprm1) reveals the identity of the neuron subtypes and also establishes spatial markers for the identification of subclasses in the striatum. Märtin et al define the molecular identity of striatal projection neurons.

And focusing on the characterization of patches and matrix compartments; Genetic labeling of neurons expressing the opioid receptor Mu (Oprm1) reveals the identity of the neuron subtypes, and also establishes spatial markers for the identification of subclasses in the striatum.

In the study, Drs. Constantine Melatis and his colleagues created a 3D molecular map of the nerve cells attacked by opioids and showed how they organize in the striatum. “Our map forms the basis for a new understanding of arguably the brain’s most important network for decision making,” said Dr. Meletis said.

“This may contribute to a better understanding of common reward processes and the impact of various addictive substances on this network.” To find this molecular code, the researchers used single-core RNA sequencing.

A method of studying small differences in individual cells and mapping striatal gene expression. The results provide the first demonstration of molecular codes that divide the striatum into three main levels of classification.

A spatial organization, a patch matrix, and a specific cell-type organization. “With this new knowledge, we can now begin to analyze the function of different types of nerve cells in different molecularly defined regions,” said Dr. Meletis said.

This is the first step to directly define the role of networks in decision making and addiction control with the help of optogenetics. The scientists said that this new knowledge may also become the basis for the development of new treatments based on the mechanistic understanding of the brain network.

The development of the new Salem map is described in an article in Cell Reports magazine.

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